http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10513467-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1996-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10513467-A |
| titleOfInvention | Farnesyl transferase inhibitors, their preparation, and pharmaceutical compositions containing them |
| abstract | (57) Abstract: Novel farnesyl transferase inhibitors of general formula (I), their preparation and pharmaceutical compositions containing them. In the general formula (I), R 1 is YSA 1- (Y is a hydrogen atom, an amino acid residue, a fatty acid residue, an alkyl or alkoxycarbonyl group, or R 4 is optionally substituted by a phenyl group. A group R 4 —S— which is a C 1-6 alkyl group, or A 1 , X 1 , Y 1 , R 2 , R ′ 2 , X 2 , Y 2 , X, R 3 , R ′ 3 , And R is a group of general formula (II) as defined below, and A 1 is optionally> C (X 1 ) (Y.sup.2) by an amino, alkylamino, alkanoylamino, or alkoxycarbonylamino group. 1 ) a C 1-4 alkylene group which is α-substituted in the group), and X 1 and Y 1 are each a hydrogen atom or a> C ＝ O group together with a carbon atom to which they are bonded, and R 2 Is a straight-chain or optionally substituted by a cyclohexyl group A branched C 1-4 alkyl group, R ′ 2 is hydrogen or alkyl, X 2 and Y 2 are each a hydrogen atom or a> C ＝ O group together with a carbon atom to which they are bonded; 3, when R 3 is an alkyl group substituted by a hydroxyl group, with the proviso that R 3 can form a lactone with α- carboxyl group, a hydroxyl optionally, alkoxy, mercapto, alkylthio, alkylsulfinyl Or a C 1-4 alkyl group substituted by alkylsulfonyl, R ′ 3 is hydrogen or alkyl, X is an oxygen or sulfur atom, and R is a hydrogen atom, or an optionally substituted Alkyl group or an optionally substituted phenyl group. These new products have anticancer properties. |
| priorityDate | 1995-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.