| abstract |
(57) Abstract: A compound of the formula (I) or a salt or solvate thereof, wherein R 1 is an alkyl group or a substituted or unsubstituted phenyl group; R 2 and R 3 are each independently And R A represents T 1 (T 1 is hydrogen or alkyl); and R B is a group of formula (a) wherein T 2 and T 3 are each independently hydrogen, hydroxy, Amino, alkoxy, alkylcarbonyloxy, optionally substituted phenoxy, optionally substituted benzyloxy, alkylamino, dialkylamino, chloro, alkyl, carboxy, carboalkoxy, carbamoyl, alkylcarbamoyl, or T 2 and T 3 are indicated by together represent the good C 3-5 alkylene chain optionally substituted with an alkyl group of each carbon atom up to three) Or represents a group; or R A together with R B, wherein (b) (R 4, R 5, R 8 and R 9 are each independently hydrogen, alkyl, substituted alkyl, aryl, substituted May be aryl, aralkyl, or R 4 and R 5 may be substituted together with the carbon atom to which they are attached, or R 8 and R 9 together with the carbon atom to which they are attached. R 6 and R 7 are each independently hydrogen, alkyl, aryl, alkoxy, or R 6 and R 7 together with the carbon atom to which they are attached form a saturated heterocyclic ring; or represents a group of formula ring to the formation); or R a is shown by the formula (c), groups R B is represented by the formula (d) (T 4, T 5, T 6 and T 7 are Each independently represents hydrogen, alkoxy, alkylcarbonyloxy, substituted Which may phenoxy, optionally substituted benzyloxy, alkylamino, dialkylamino, chloro, alkyl, carboxy, carbalkoxy, carbamoyl or alkylcarbamoyl, or X 1 and Y are each independently hydrogen or X 1 is C 3-5 alkylene chain together with Y, wherein,: -CO-NH -, - CH 2 -NH- or a group represented by -CH 2 -O-) represents; X Is hydroxy, alkoxy or a group of the formula: NR s R t wherein R s and R t are each independently hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl or heteroarylalkyl preparation of such compounds; indicates either or R s and R t represent a saturated heterocyclic group together with the nitrogen atom to which they are attached) Pharmaceutical compositions comprising a compound such as and use in medicine such compounds. |