http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10511267-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1132 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 1995-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10511267-A |
| titleOfInvention | Synthesis of stereospecific oligonucleotide phosphorothioates |
| abstract | (57) [Summary]nDisclosed are methods for synthesizing stereospecific (Rp) phosphorothioate oligonucleotides. In this method, a primer comprising a plurality of deoxyribonucleotides and one ribonucleotide at the 5 'end or at the second position from the 5' end is annealed to the template. This construct is contacted with a mixture of deoxynucleoside α-triphosphate Sp diastereomer and DNA polymerase to form a PS-Rp oligodeoxynucleotide extension, which is cleaved after the ribonucleotide in the primer. The oligodeoxynucleotide is released as a single-stranded PS-Rp oligonucleotide. Also disclosed are PS-Rp oligonucleotides and oligonucleotides prepared according to the methods of the invention. |
| priorityDate | 1994-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.