http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10509586-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 1995-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10509586-A |
| titleOfInvention | Transgenic non-human animal having a functionally disrupted interleukin-1β converting enzyme gene |
| abstract | (57) Abstract: A transgenic non-human animal having somatic cells and germ cells in which at least one allele of an endogenous interleukin 1β converting enzyme (ICE) gene is functionally disrupted is provided. The animal may be heterozygous for ICE gene disruption, but is more preferably homozygous, and is preferably a mouse. In homozygous animals, secretion of mature interleukin-1β and interleukin-1α is substantially reduced as compared to non-mutated animals. Using the animals of this invention as a positive control, the efficacy of the ICE inhibitor can be evaluated and pathologies treatable with the ICE inhibitor can be identified. Also provided is a transgenic non-human animal having a functionally disrupted endogenous ICE gene, but reconstituted with the human ICE gene. This animal can be used to identify agents that inhibit human ICE in vivo. A nucleic acid construct for functionally disrupting an endogenous ICE gene in a host cell, a recombinant vector containing the nucleic acid construct, and a host cell into which the nucleic acid construct has been introduced are also encompassed by the present invention. |
| priorityDate | 1994-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 593.