http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10508202-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 1995-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10508202-A |
| titleOfInvention | Tumor-specific antibody fragments, fusion proteins, and uses thereof |
| abstract | (57) Abstract The present invention provides recombinant single-chain antibodies that specifically bind to Lewis Y- related homogeneous antigens and fusion proteins comprising those antibodies. More specifically, the present invention provides a single-chain Fv (scFv) region of monoclonal antibodies B1, B3 and B5, a humanized single-chain Fv region of B1, B3 and B5, and a fusion protein comprising those scFvs. provide. The present invention also provides for a number of stabilizing mutations in Lewis Y binding monoclonal antibody B3. In addition, the present invention provides a method for detecting cells having Lewis Y antigen in a patient and a method for killing or suppressing the proliferation of cells having Lewis Y antigen in a patient. The present invention also provides a method of improving the binding affinity of an antibody lacking serine at position 95 of the VH region, comprising changing position 95 to serine. |
| priorityDate | 1994-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.