| abstract |
(57) Abstract: The present invention provides a 2-ureido-benzamide derivative compound having the general formula (1) or a pharmaceutically acceptable acid addition salt thereof. Wherein R 1 is H, a halogen atom, an alkyl group, an alkoxy group or a dialkylamino group, and R 2 is H, a halogen atom, a hydroxy group, a nitro group, an alkyl group, an alkoxy group, a cycloalkylmethoxy group, an alkylthio group. X is an alkyl group, a cycloalkyl group, a cycloalkyl group, an alkylsulfinyl group, an alkylsulfonyl group or a group (II) wherein j, R 3 and R 4 are as described in the specification. A methyl group, an alkoxyalkyl group or a group (III) (where k, R 5 and R 6 are as described in the specification), Y is H or an alkyl group, and Z is a group (IV ), Group (V) or group (VI) (wherein m is an integer of 0 to 4, and groups (VII), A 1 , A 2 , R 7 and R 8 are as defined in the description) ) Or -NYZ can be taken together to form a ring]. The compounds are useful as ACAT inhibitors. |