| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0808 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-12 |
| filingDate |
1995-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
1998-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-H10506897-A |
| titleOfInvention |
Inhibitors of farnesyl-protein transferase |
| abstract |
(57) [Summary]nThe present invention includes analogs of the CAAX motif of the protein Ras that are modified by farnesylation in vivo. These CAAX analogs inhibit farnesylation of Ras. Furthermore, these CAAX analogs differ from those previously described as inhibitors of Ras farnesyl transferase in that these CAAX analogs do not have a thiol moiety. The unique advantages of thiol deficiency include improved pharmacokinetic behavior in animals, prevention of thiol-dependent chemical reactions such as rapid autoxidation and disulfide formation with endogenous thiols, and reduced systemic toxicity Bring. Furthermore, chemotherapeutic compositions containing these farnesyltransferase inhibitors and methods for producing them are included in the present invention. |
| priorityDate |
1994-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |