http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10505502-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate | 1995-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10505502-A |
| titleOfInvention | Preparation of modified collagen-induced platelet aggregation inhibitor paridipine |
| abstract | (57) [Summary]nThe present invention provides a method for producing a recombinant protein called Asp-paridipine. Asp-paridipine inhibits collagen-induced platelet aggregation of mammalian platelets. The Asp-paridipine is (i) a protein (Pallidipin) selected from the group of paridipine proteins, and (ii) the amino acid aspartic acid, wherein the aspartic acid is connected to the N-terminus of paridipine by a peptide bond. )). The method comprises the following steps: aa) (i) DNA or cDNA encoding the above recombinant Asp-paridipine; Transforming at least one bacterium with a suitable vector comprising a suitable signal peptide sequence such that the peptide is cleaved, and (iii) a suitable promoter; bb) a preprotein comprising Asp-paridipine and said signal sequence Cc) transports the Asp-paridipine from the bacterial cytoplasm into the periplasmic space and cleaves the preprotein with at least one protease during the transport to create Asp-paridipine; dd) Isolating the Asp-paridipine by extracting the periplasmic space; and ee) the Asp-paridipine Purifying the pins. The protein is used as an agent for inhibiting collagen-induced human platelet aggregation or cancer with metastatic tumor cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002539788-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4805461-B2 |
| priorityDate | 1994-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.