| abstract |
(57) [Summary]nThe present invention relates to a method for synthesizing optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acid from optically pure aldehyde. The invention also relates to the use of such optically pure compounds as potent platelet aggregation inhibitors by acting at the level of cyclooxygenase, the treatment of both acute and chronic inflammation and cachexia, rheumatoid arthritis, multiple occurrences It is effective in treating multiple sclerosis, Crohn's disease and ulcerative colitis. The present invention also relates to pharmaceutical compositions of the compounds. |