| abstract |
Certain substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of the 5-HT 1 -like receptor and are effective agonists of the human 5-HT 1D α receptor subtype, -HT 1D has at least 10-fold selective affinity as compared with the case of the β subtype to 5-HT 1D alpha receptors subtypes, therefore, is a subtype selective agonist of 5-HT 1D receptors Useful for the treatment and / or prevention of required clinical symptoms, especially migraine and related diseases, and has fewer side effects, especially cardiovascular adverse effects, than non-subtype selective 5-HT 1D receptor agonists . |