| abstract |
(57) The compound having the formula (I): In the formula, Z represents a methylene group, a methine group, a group of the formula> NH or a group of the formula>Nā; and W is a methylene group, a methine group, a sulfur atom or a formula> S ā (O) v ( wherein, v is 1 or 2) indicates;. ... represents a single bond or a double bond, at least one of Y 1, Y 2, Y 3 and Y 4 are carboxy groups, sulfonamido A group or a formula-(A) p -B 1 -T 1 wherein A represents S or O; T 1 represents a carboxy group, a thiocarboxy group, a dithiocarboxy group, a sulfonamide group, or a tetrazolyl group; B 1 represents a bond, an optionally substituted alkylene group; p represents 0 or 1); and the remaining Y 1 , Y 2 , Y 3 and Y 4 groups are Same or different, H, halogen, nitro, OH, SH, NH 2 , optionally substituted alkyl , Alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aryl, aralkyloxy, aralkylthio; and Y 1 and Y 2 may together represent lactone or keto; one of R 1 and R 2 is, H, alkyl, alkanoyl, aryl, arylcarbonyl, aralkyl, carboxy, sulfonamide or formula, - (O) q -B 1 -T 2 ( wherein, T 2 is, COOH, shows a sulfonamide or tetrazolyl; B 2 represents an optionally substituted alkylene; q is 0 or 1.); the other of R 1 and R 2 represents H, alkyl, aryl or aralkyl, or Is a group wherein R 1 and R 2 together have the formula (1b ā²): [R 10 , R 11 and R 12 are the same or different and each represents H, OH, halogen, haloalkyl, optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl. R 3 represents H or a protecting group for an amino group. And pharmaceutically acceptable salts thereof are allosteric effectors at the muscarinic receptor and are useful in the treatment and prevention of disorders associated with the muscarinic receptor. |