http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10503220-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 |
| filingDate | 1996-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10503220-A |
| titleOfInvention | Substituted camptothecin derivatives and method for producing the same |
| abstract | (57) [Summary] The present invention provides a compound of formula (I) [wherein the symbols --- represents a single bond or a double bond; R 1, R 2 and R 3 are as defined in the following (a) or (b): phenyl ring with be substituted;; (a) R 1 and R 2 are each independently hydrogen; C 1 -C 4 alkyl; C 3 -C 7 cycloalkyl; phenyl C 1 -C 6 alkyl -NR 5 R 6 wherein one of R 5 and R 6 is hydrogen, C 1 -C 6 alkyl or benzyl, and the other is hydrogen, C 1 -C 6 alkanoyl, optionally substituted C 1 -C 6 alkoxycarbonyl Benzoyl, phenyl C 1 -C 6 alkanoyl which may be substituted, C 1 -C 6 alkoxycarbonyl which may be substituted, phenoxycarbonyl or phenyl C 1 -C 6 alkoxycarbonyl which may be substituted. Or Other R 5 and R 6 form a heteromonocyclic ring residue which may be substituted they are saturated 4-7 membered together with the attached nitrogen atom); COOR 8 (wherein R 8 is hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or phenyl C 1 -C 6 alkyl); or COR 9, wherein R 9 is C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, phenyl C 1 -C 6 alkyl, optionally substituted phenyl ring or NR 10 R 11 wherein R 10 and R 11 are each independently hydrogen or C 1 -C 6 alkyl R 3 is hydrogen, C 1 -C 6 alkyl or an optionally substituted phenyl ring; or (b) R 1 and R 3 together are 5-8 membered substituted a certain form a ring carbon monocyclic; R 2 is hydrogen, C 1 -C 4 Be alkyl or C 3 -C 7 cycloalkyl; R 4 is hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or phenyl C 1 -C 6 alkyl; X is hydrogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, C 3 -C 7 cycloalkoxy, C 1 -C 6 alkanoyloxy, benzoyloxy, amino, hydroxy, nitro, halogen, or molecule A methylenedioxy group bonded to positions 10 and 11 of the above) and a pharmaceutically acceptable salt thereof. The compounds according to the invention are useful therapeutically as antitumor agents. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017507170-A |
| priorityDate | 1995-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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