| abstract |
(57) [Summary]nInflammation associated with trauma, as well as rheumatoid arthritis, psoriasis, insulin-dependent diabetes, cutaneous lymphoma, duodenal ulcer, chronic proctitis, lymphocytic thyroiditis, hemorrhagic shock, reperfusion injury during transplantation and multiple sclerosis The composition is administered to a patient (preferably by injection and topically) to treat a variety of conditions, including inflammation associated with certain embodiments of the disease. These compositions are pharmaceutically acceptable injectable preparations containing the active ingredient in a pharmaceutically acceptable carrier. Its active ingredient is a chlorate or selenate that inhibits the natural biochemical sulfation process and / or a sulfatase enzyme that removes the sulfate group from a specific position on the sugar molecule that forms part of the natural ligand for L-selectin. is there. Removal of the sulfate group from the ligand interferes with the ability of the ligand to bind to its natural receptor (i.e., L-selectin), thereby disrupting the biochemical chain events that lead to inflammation. |