| abstract |
(57) [Summary] (With correction) [Solution] The following formula (I) Wherein R 1 is a hydrocarbon group, a heterocyclic group or an amino group, n Is 1 or 2, R 2 is a cyano group, an acyl group, a carbamoyl group, a thiocarbamoyl group, a carboxyl group which may be esterified, a vinyl group, an ethynyl group, an amidino group or a logenomethyl group, and R 3 is a carbon atom Represents a group. Provided that when R 2 is an ethoxycarbonyl group, R 1 represents a hydrocarbon group or a heterocyclic group], a thiazole derivative or a salt thereof, a process for producing the thiazole derivative and a medicament containing the derivative. [Effects] The above compounds have an excellent inhibitory action on NO production from iNOS-induced cells, an inhibitory action on IL-6 activity, and the like. It is useful as a medicament such as a prophylactic / therapeutic agent for diseases such as cerebral ischemic disorder, Alzheimer's disease, multiple sclerosis, sepsis, rheumatoid arthritis, osteoarthritis, gastric ulcer, and duodenal ulcer. |