| abstract |
(57) Abstract: 100n with or without a target molecule A method for the production of highly monodispersed polymer hydrophilic nanoparticles having dimensions up to m and high monodispersity is provided. SOLUTION: The method of the present invention comprises, in a step, dissolving a surfactant in oil to obtain reverse micelles; an aqueous solution of a monomer or a preformed polymer in the reverse micelles, a crosslinking agent, an initiator and Adding a drug and, if necessary, a target substance; subjecting the mixture to a polymerization step; removing the solvent and drying the polymerization reaction product to obtain a dry aggregate comprising dry nanoparticles and a surfactant. Dispersing the dried aggregate in an aqueous buffer; and separating surfactants and other toxic substances therefrom. |