| abstract |
(57) [Summary] Formula (I): A topical ophthalmic cytokine production inhibitor comprising an amide compound represented by the formula (1) as an active ingredient. [Effect] Compound [I] has an excellent inhibitory action on local cytokine production in the eye, particularly an inhibitory action on IL-6 production and TNF-α production. For example, ocular inflammation such as uveitis, ocular symptoms such as iridocyclitis seen in chronic inflammatory diseases (Behcet's disease, sarcoidosis, etc.), autoimmune diseases (rheumatoid arthritis, Ocular symptoms such as episcleritis, scleritis, keratoconjunctivitis sicca, uveitis, iridocyclitis, and keratitis due to infections (such as viral infections) seen in juvenile rheumatoid arthritis) It is useful for prevention and treatment of ocular symptoms such as. |