| abstract |
PROBLEM TO BE SOLVED: To provide an ASP2 polypeptide and polynucleotide and a method for producing the polypeptide by a recombinant method. SOLUTION: The nucleotide sequence encoding the ASP2 polypeptide of SEQ ID NO: 2 has at least 8 A polynucleotide comprising a nucleotide sequence that is 0% identical and that encodes a polypeptide having the activity of an ASP2 polypeptide, or a nucleotide sequence that is complementary to this nucleotide sequence, is isolated. The ASP2 polypeptides and polynucleotides are useful in the treatment of Alzheimer's disease, cancer, dysfunctions or diseases including prohormone processing, and diagnostic assays for such conditions. |