| abstract |
(57) Abstract: The present invention has an excellent acyl-coenzyme / cholesterol / acyltransferase inhibitory action, An amide derivative or a urea derivative useful as a therapeutic or prophylactic agent for atherosclerotic disease is provided. The amide derivative or urea derivative has a general formula: [R 1 : alkyl group; R 2a , R 2b , R 2c and R 2d : H, A halogen, a displaceable alkyl group, an alkoxy, an alkylthio, an alkylsulfinyl, an alkylsulfonyl, or an alkanoyl or an adjacent R 2a and R 2b together form an alkylenedioxy group; R 3 : an alkyl group; A: a single bond or an alkylene group B: alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, monoalkylsulfamoyl, dialkylsulfamoyl, Sulfamoylamino, monoalkylsulfamoylamino or dialkylsulfamoylamino groups; n: 0 or 1]. |