| abstract |
(57) [Summary] [Problem] Immunophilin protein, particularly peptidyl- Provided is a small molecule compound having affinity for FKBP-type immunophilin for use as an inhibitor of an enzyme activity related to prolyl isomerase or rotamase activity. Kind Code: A1 A neurotrophic low molecular weight small molecule N-oxide [3- (3-pyridyl) -1-propyl (2S) -1-) of a heterocyclic ester, amide, thioester or ketone. (3,3-dimethyl-1,2-dioxopentyl) -2 -Pyrrolidine carboxylate, N-oxide, etc.] A pharmaceutical composition comprising a neurotrophically effective amount of the above N-oxide and a carrier. A method for stimulating damaged neurons, promoting neuron regeneration, preventing neurodegeneration, treating neurological disorders (Alzheimer's disease, Parkinson's disease, muscle atrophy) comprising administering a neurotrophic effective amount of the above N-oxide to animals. Lateral sclerosis). |