| abstract |
PROBLEM TO BE SOLVED: To provide a mefenamic acid aqueous solution preparation having a concentration effective for anti-inflammatory action of mefenamic acid, which is extremely poorly soluble in water, expected as an ophthalmic solution or injection solution. SOLUTION: An aqueous mefenamic acid preparation comprising mefenamic acid containing a basic substance, polyvinylpyrrolidone and a nonionic surfactant of HLB 14-15. Further, a mefenamic acid aqueous solution for eye drops, in which the irritation of mefenamic acid to the eye is remarkably reduced by adding a certain amino acid and chlorobutanol in combination to the mefenamic acid aqueous solution formulation described above. |