http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10298177-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e43b4ca6b41ce9f54c9a895d474c81a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-357 |
| filingDate | 1997-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_734a554a3d72276ea22738a3bdd6938d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_378f06d885be358449007ef6988a9c55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2509cbc8e666318f687d5fbbdf293ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31a91a3b471b894b9124b5967bee0b51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc0ae13a25ae8629fbe96e648eb87d46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a11b8485b39cda749bfb485d18b250b3 |
| publicationDate | 1998-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10298177-A |
| titleOfInvention | Novel tartaric acid derivatives, their uses and manufacturing method |
| abstract | (57) [Summary] [PROBLEMS] A therapeutic agent for infectious diseases such as a therapeutic agent for mycosis or a cardiovascular disease such as hypercholesterolemia, hyperlipidemia, and arteriosclerosis by inhibiting squalene synthase. Provide novel tartaric acid derivatives, which are expected as therapeutic drugs. SOLUTION: General formula (1) (Wherein, A 1 and A 2 each represent hydrogen or an aromatic ring group which may have a substituent. X 1 and X 2 each represent a linear or branched group which may have a substituent. Chain carbon number 1-2 Represents an alkylene group of 0. However, A 1 X 1 and A 2 X 2 Are both alkyl groups having 1 to 3 carbon atoms, and both are benzyl groups. The configuration of the three carbons on the dioxolane ring may be either the R configuration or the S configuration, The compound represented by any of optically active form and racemic form) or a pharmaceutically acceptable salt thereof has strong squalene synthase inhibitory activity and antifungal activity, and is a therapeutic agent for infectious diseases such as a therapeutic agent for mycosis. Or, it is useful as a drug such as a drug for treating cardiovascular diseases such as hypercholesterolemia, hyperlipidemia, and arteriosclerosis. |
| priorityDate | 1997-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.