| abstract |
(57) [Summary] (with correction) [PROBLEMS] To provide a COX-II selective inhibitor. SOLUTION: The following formula (I) Wherein R 1 is substituted aryl, substituted lower alkyl, etc., R 2 is substituted aryl, R 3 is hydrogen, Halogen, carboxy, esterified carboxy, X represents O or NR 4 , and NR 4 represents hydrogen or substituted lower alkyl such as acyl], and a salt thereof. [Effect] Compound (I) and a salt thereof are COX-II It has a selective inhibitory activity and is useful as an anti-inflammatory and analgesic. |