| abstract |
(57) [Problem] To provide a compound which can be used for treating diseases of the central nervous system. SOLUTION: γ-propylidene-L-glutamic acid, γ -Ethylidene-L- glutamic acid and γ-methylidene-L- Compounds having the following formula other than glutamic acid, or salts or esters thereof. Embedded image Wherein n is 1 or 2, R 1 is —CO 2 H, R 2 is hydrogen or C 1-4 alkyl, and R 3 is Is hydrogen, C 1-10 alkyl, C 2-10 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C 1-4 Alkyl, optionally substituted phenyl-C 2-10 alkenyl, (optionally substituted phenyl) 2 -C 1-4 alkyl, optionally substituted C 3-7 cycloalkyl, optionally substituted C 3 -7 cycloalkyl-C 1-4 alkyl or optionally substituted C 3-7 cycloalkyl-C 2-10 alkenyl, or R 2 and R 3 are carbon atoms attached to form a cycloalkyl group C 4-7, optionally substituted with atoms. ) |