| abstract |
(57) [Problem] To provide a method for industrially and advantageously producing a cyclohexylidene derivative in a highly stereoselective manner under mild conditions. SOLUTION: General formula (I) (Wherein, R 1 , R 2 , R 3 and R 4 represent a hydrogen atom, a hydroxyl group, etc., and R 5 represents a hydroxyl group or an alkoxy group) Wherein the octadiene derivative obtained by reacting the heptenone derivative represented by the formula (1) with malonic acid or its ester or a salt thereof, and then with a trifluoromethanesulfonic acid derivative is cyclized in the presence of a palladium catalyst; ) (Wherein R 11 represents a hydroxymethyl group or the like). |