| abstract |
PROBLEM TO BE SOLVED: To provide a pharmaceutical preparation containing human growth hormone having a molecular weight of about 20,000 and having improved solubility and stability in an aqueous solution after lyophilization and redissolution. SOLUTION: At least one or more water-soluble heterocyclic compounds selected from creatinine, sodium acetyltryptophan and nicotinamide, a basic amino acid or a salt thereof and a nonionic surfactant are added to an aqueous solution of human growth hormone having a molecular weight of about 20,000. In addition, a lyophilized formulation is produced. Effect of the Invention According to the present invention, it is possible to provide a pharmaceutical preparation suitable for use as an injection, which contains human growth hormone having a molecular weight of about 20,000 at a concentration suitable for a pharmaceutical and can be stably maintained even after freeze-drying and reconstitution. . |