| abstract |
(57) Abstract: A branched oligonucleotide represented by the formula (1) and a pentaerythritol compound represented by the formula (2) (R 1 and R 2 are RNA or DNA, and Tr is a substituent Optionally a trityl group, A is a phosphate, phosphonate or phosphoramidite, and n is 2 to 6). Embedded image Embedded image Effect: If the pentaerythritol compound (2) is used, the four-way branched oligonucleotide (1) can be easily obtained by the solid phase phosphoramidite method. This branched oligonucleotide (1) is useful as an antisense molecule because it forms a triple-stranded nucleic acid with various DNAs and RNAs. |