| abstract |
(57) [Summary] [Constitution] Formula (I) Or a prophylactic / therapeutic agent for a proliferative disease, or an inhibitor of epidermal growth factor receptor tyrosine kinase activity, comprising a compound represented by the formula: or a pharmacologically acceptable salt thereof as an active ingredient. [Effects] EGF-R tyrosine kinase activity is strongly suppressed, and proliferative diseases such as tumors that are malignant proliferative diseases of epithelial origin (eg, breast cancer, esophageal cancer, bladder cancer, ovarian cancer, vulvar cancer, colon cancer, Lung cancer, melanoma, oral cancer and brain tumor), or benign proliferative diseases of the epidermis, such as psoriasis, pulmonary fibrosis, and polycystic kidney disease. |