| abstract |
PROBLEM TO BE SOLVED: To provide an effective anticoagulant activity by both an APTT activity / coagulation mechanism and an antithrombin activity, and to provide a low molecular weight fucan sulfate having a more effective antithrombotic activity. . SOLUTION: On a dry weight basis: 12.5 sulfur ~ 15%, fucose 43-57%, uronic acid 2-9%, Molecular weight 14,000-29,000 daltons, specific light intensity -130 ° -170 °, APTT titer 40-80 Low molecular weight fucan sulphate obtained from gypsum or pheophysis characterized by a U./mg and a TT titer of 18-30 IU / mg. |