http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H10182462-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_324beb8b942a3a6ed1f1f576bcd76c45 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate | 1997-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94316ab9163b0b8edc51a23bd63b33f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a834186f928684745e1003ead88fe9a7 |
| publicationDate | 1998-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H10182462-A |
| titleOfInvention | Cytokine production inhibitor containing 1,6-naphthyridine derivative as active ingredient |
| abstract | (57) [Summary] (Constitution) (+)-(R) -1,4-dihydro-5-isopropoxy-2-methyl-4- (2-trifluoromethylphenyl) -1,6-naphthyridine-3 The present invention relates to a cytokine production inhibitor and a liver disease therapeutic agent containing ethyl carboxylate as an active ingredient [Effect] The above-mentioned active ingredient suppresses the production of TNFα and IL-6 by treatment of macrophage cultured cells with LPS, and the TNFα and IL-6 in plasma after administration of Con A. And is useful as an inhibitor of cytokine production, and in a mouse liver injury model induced by ConA, it significantly suppresses an increase in serum GOT and GPT, and is also useful as a therapeutic agent for liver disease . |
| priorityDate | 1996-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.