abstract |
(57) [Summary] The following formula [A represents CR 4 or a nitrogen atom; R 1, R 2, R 3 , and R 4 represents a hydrogen atom, a fluorine atom, or a nitro group; Q is - [C (R 5) ( R 6)] - a group represented by (R 5 and R 6 represents a hydrogen atom or a C 1-4 alkyl group) or a single bond; Y represents an isoxazolyl group, a pyrazolyl group, a phenyl group, an indanyl group, a naphthyl group, an unsubstituted biphenyl group, a cyclohexyl group, or —CH (COR 7 ) a group represented by (COR 8 ) (R 7 and R 8 are C 1-4 alkyl groups)]. [Effect] As an anti-androgen agent, it is useful for prevention and / or treatment of diseases such as prostatic hypertrophy and prostate cancer. Embedded image |