| abstract |
(57) [Problem] To provide a Na + / H + exchanger inhibitor excellent in specificity and free from side effects. SOLUTION: A 3-arylacryloylguanidine derivative represented by the following general formula (I) or a salt thereof. Embedded image (However, the symbols in the formula have the following meanings: X: oxygen atom or sulfur atom, n, m: one of them is 1, the other is 0 or 1, A: a lower alkylene group, R 1 : protected A hydroxyl group which may be protected, an amino group which may be protected, a mono-lower alkylamino group which may be protected, or a di-lower alkylamino group, R 2 , R 3 : the same or different, a hydrogen atom, or A lower alkyl group optionally substituted by a halogen atom, R 4 : a hydrogen atom, a halogen atom or a lower alkoxy group.) |