| abstract |
(57) [Summary] [PROBLEMS] To provide an agent capable of acting on tumor cells to suppress the proliferation thereof. SOLUTION: The matrix metalloproteases (M Pharmaceuticals containing at least one selected from the group consisting of tissue inhibitors of metalloproteases (TIMPs), which are inhibitors of MPs), have an activity of directly acting on tumor cells and inhibiting their proliferation. . In particular, TIMP-2 has excellent properties as a medicine, and human rTIMP-2 is a practical antitumor agent, Particularly, it is very useful as a malignant tumor growth inhibitor or a therapeutic agent for cancer. |