| abstract |
(57) [Summary] [Problem] To provide a novel anti-therapeutic agent and the like. SOLUTION: A complex comprising an antibody against integrin α3 or a fragment thereof having an antigen-binding property and a chemotherapeutic agent or a toxin, and a pharmaceutical composition comprising the complex. [Effect] By internalization of anti-integrin α3 antibody, a chemotherapeutic agent or a toxin is efficiently taken into cells, particularly tumor cells, and exerts a cell killing activity. |