| abstract |
(57) Abstract: The present invention relates to a cholecystokinin (CCK) antagonist comprising a 2-acylaminothiazole compound as an active ingredient. SOLUTION: Formula: embedded image Wherein R 1 and R 2 represent H or alkyl; R 3 is an optionally substituted cycloalkyl or an optionally substituted aromatic group, and represents phenyl or a heterocyclic ring containing one or more hetero atoms selected from O, S and N; R 2 and R 3 together The carbon of the optionally substituted phenyl may be attached at the 4-position of the thiazolyl ring, and Z comprises one or more heteroatoms selected from O, S and optionally substituted N. And a substituted or unsubstituted heterocyclic ring], and an addition salt of an acid or base of these compounds as an active ingredient, a cholecystokinin (CCK) antagonist. |