| abstract |
PROBLEM TO BE SOLVED: To provide a skin whitening external preparation having a high melanin production inhibitory effect, high stability and safety, and having no undesirable color or odor. SOLUTION: Itari ( Polygonum cuspidatum Sieb. et Zucc.), Honey beebird ( Polygonum cuspida) tum Sieb. et Zucc. var. hachidyoense Ohwi), and Ooitadori (Polygonum sachalinense Fr. Schm. One or extract with a polar solvent of two or more plants selected from) and concentrated under reduced pressure, re to 30 volume% ethanol After dissolution and fractionation by resin column chromatography, 40 The fraction containing (-)-epicatechin, which is obtained by further fractionating the fraction eluted with ethanol by volume of silica gel by silica gel chromatography, is contained in the external preparation base. An appropriate content is about 0.0001 to 5.0% by weight. |