| abstract |
(57) [Summary] PROBLEM TO BE SOLVED: To extract rain and diacerein used as therapeutic agents for osteoarthritis from industrial products in a high yield, instead of extracting them from a large amount of plant resources (senna leaves, etc.) as in the past A method for synthesis is provided. SOLUTION: R 1 is -OR ', -NR'R ", -SR', R 'and R" are H, alkyl or aromatic groups, and R 2 is H Or a diphenyl ketone in which R 3 is —OH or a C 1 -C 4 alkyl group. Treated with an acid or superacid to the 1-aminoanthraquinone derivative, substituted diazotization, a -NH 2 group by -OH, perform any removal and acylation of the protecting group. |