| abstract |
(57) Abstract: To provide a mutant in which the amino acid at position 358 of alpha-1-antitrypsin is substituted with valine or arginine, and a pharmaceutical composition containing the same. SOLUTION: Position 35 of alpha-1-antitrypsin A mutant in which 8 amino acids have been replaced by valine or arginine; cells producing it; genetic antitrypsin deficiency containing it, emphysema and / or other lungs associated with progressive digestion of the lung sac. A pharmaceutical composition for the treatment of a disease, cystic fibrosis, or arthritis. |