abstract |
PROBLEM TO BE SOLVED: To provide an aprotinin mutant having improved enzyme inhibitory, immunological and pharmacokinetic properties. SOLUTION: The compound has a net charge of +3 to -3 at pH 7 and has an amino acid Arg15 or Arg15 in a binding region. An aprotinin variant having Ala17, and a medicament comprising one or more of the aprotinin variants. |