| abstract |
(57) [Problem] To provide a novel compound having an apoptotic nerve cell death inhibitory activity. SOLUTION: An isoquinoline derivative represented by the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof. Wherein Ar is an optionally substituted aromatic ring, n Represents 0, 1, and 2, respectively. [Effect] The compound of the present invention has an effect of suppressing neuronal cell death, and has neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, and cerebral ischemic disorders such as stroke. And useful as preventive and therapeutic agents for peripheral neuropathy and the like observed in diabetes and the like. |