| abstract |
(57) [Abstract] [PROBLEMS] An artificial antigen derived from HP urease protein, which can be used as a vaccine or the like against Helicobacter pylori (HP) infection, which is said to contribute to digestive organ lesions, And an anti-HP urease antibody induced by the artificial antigen. The artificial antigen (UB-33) of the present invention has the following general formula (1): Cys-His-His-Leu-Asp-Lys-Ser-Ile-Lys-Glu-Asp-Val-Gl. n-Phe-Ala-Asp-Ser-Arg-Ile A peptide having the amino acid sequence represented by (1), a fragment thereof, or a mutant equivalent thereto. The minimum antigenic determinant is represented by the following general formula (4). Ser-Ile-Lys-Glu-Asp-Val-Gln-Phe … (4) |