| abstract |
(57) [Summary] (Modified) [Solution] A CHO cell having an ability to continuously produce a recombinant human melatonin receptor protein, a recombinant human melatonin receptor protein isolated from the CHO cell, or Screening of a partial peptide, a method for producing the recombinant human melatonin receptor protein, the CHO cell line, a melatonin receptor affinity compound or a salt thereof using the recombinant human melatonin receptor protein or the partial peptide A method, a screening kit, a melatonin receptor affinity compound or a salt thereof obtained by the screening method, and a pharmaceutical composition containing the compound. [Effect] By using the above CHO cells or the above receptor protein to screen for a compound having affinity for melatonin receptor, prostate cancer, uterine cancer, breast cancer, pituitary tumor, benign prostatic hyperplasia, endometriosis, uterine myoma, A preventive / therapeutic agent for precocious puberty, a pregnancy regulator, a menstrual cycle regulator, etc. can be provided. |