| abstract |
(57) Abstract: M-CS specifically reacting with M-CSFR Monoclonal antibody against FR, hybridoma producing the antibody, method for detecting M-CSFR, monoclonal antibody against M-CSFR and c-kit A method for separating and purifying monocyte / macrophage progenitor cells using a monoclonal antibody against. [Effect] A monoclonal antibody specific to M-CSFR is provided, and an immunoassay method capable of easily detecting and measuring M-CSFR and cells having M-CSFR with high sensitivity and accuracy is provided. The antibody of the present invention is M-C Since it has the property of neutralizing the action of M-CSF on cells functionally expressed in response to SF, studies of differentiation of bone marrow cells into macrophages, studies of differentiation of hematopoietic stem cells into osteoclasts, metabolism of qualities , A method of studying the role of M-CSF signaling in arteriosclerosis studies. Furthermore, using the antibody of the present invention and the term c-kit antibody, By separating the cells, a method for separating and purifying monocyte / macrophage progenitor cells is provided. |