| abstract |
(57) [Summary] [PROBLEMS] To find an orally administrable drug having a highly active vascular smooth muscle cell proliferation inhibitory action, which is strongly expected as a drug for preventing restenosis after PTCA. SOLUTION: The following formula [1] [In the formula, X is a halogen atom located in ortho, meta or para, a cyano group, an amide group, an aminomethyl group, a linear or branched α-hydroxyalkyl group, an optionally substituted amino group, a hydroxyl group. Represents an alkoxy group, an alkyl group, an aryl group, a halogen-substituted alkyl group, an ester group, a carboxyl group, or a carbamoyl group, m Is 0 or 1 and n is an integer from 0 to 4. ] The compound represented by these, and / or isocarba cyclins which are its enantiomers. |