| abstract |
(57) Abstract: An anti-inflammatory agent having antipyretic / analgesic action and anti-inflammatory action, particularly an action of selectively inhibiting cyclooxygenase-2 (COX-2), and having few side effects such as gastrointestinal disorders. An oxazole-based heteroaromatic compound useful as the above or a pharmaceutically acceptable salt thereof is provided. SOLUTION: General formula (I) [In the formula, Z is an oxygen atom, and one of R and R 1 is (In the formula, R 3 is an alkyl group, an amino group or an alkylamino group, at least one of R 4 , R 5 , R 6 and R 7 is a halogen atom or a lower alkyl group, and the rest are hydrogen atoms. Or a halogen atom, and the other is a cycloalkyl group which may be substituted, a heterocyclic group which may be substituted or a phenyl group which may be substituted, and R 2 is a lower alkyl group]. A heterocyclic aromatic compound or a pharmaceutically acceptable salt thereof. |