| abstract |
(57) [Summary] The substituted sulfonamide represented by the formula (I) is a selective β 3 -adrenergic receptor agonist having almost no β 1 and β 2 -adrenergic receptor activity, and the compound itself increases intracellular energy consumption and lipolysis. Can be made. That is, this compound has high activity in the treatment of type II diabetes and obesity. This compound can also be used for lowering triglyceride and cholesterol levels, increasing high density lipoprotein levels, or decreasing intestinal motility. In addition, this compound can be used for the reduction of neurogenic inflammation or as an antidepressant. This compound is prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Also included is the use of the compositions and methods to treat diabetes and obesity, lower triglyceride and cholesterol levels, increase high density lipoprotein levels, or increase intestinal motility. |