| abstract |
(57) Abstract: The present invention provides a compound represented by the formula (I): And N-oxides if chemically possible and S-oxides if chemically possible and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof, wherein , A, B and D represent the various ring systems described in the specification, R 1 represents one of the various groups described in the specification, R 3 is a hydrogen atom or C 1 -C 4 -alkyl. the stands, Z is the formula - (CH (R 5)) m -, - (CHR 5) p CR 5 = CR 5 (CHR 5) q -, - (CHR 5) r C (= O) CR 5 (CHR 5) s - or - (CHR 5 t) C ( = O) (CHR 5) u - represents, m in the formula is 2, 3 or 4, p and q is independently 0, 1 or 2 Yes, but p + q is not greater than 2, one of r and s is 0, the other is 1, and t and u are irrelevant A is 0, 1, 2 or 3, provided that t + u is not greater than 1, not greater than 3, R 5 represents a hydrogen atom, methyl, ethyl, hydroxy, methoxy or ethoxy. The present invention further relates to a method for producing the above compounds, salts, esters and amides, their use as therapeutic agents, and pharmaceuticals containing them. |