| abstract |
(57) Summary A compound of formula (I), wherein A is selected from rings 1, 2 and 3, where R is a CH 2 group, or a sulfur, oxygen or nitrogen atom substituted by an alkyl group, Salts, their manufacture, and medicaments containing them. The compounds of formula (I) are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists having useful pharmacological properties, also known as quisqualate receptors. . Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, especially NMDA receptor glycine regulatory site ligands. |