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filingDate 1994-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1997-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H09510689-A
titleOfInvention Indole derivatives as antiestrogens
abstract (57) Summary The present invention discloses indole derivatives of formula (I). [Wherein R 1 and R 2 independently represent hydroxy, methoxy or fluorine, preferably hydroxy, n represents an integer from 9 to 12, and X represents CONR4R5, CSNR4R5, NR4COR5, NR4R5, SO 2 NR4R5, NR4SO 2 R5,1-R4-5- part of the group consisting of tetrazole, wherein R4 and R5 is selected from hydrogen and lower alkyl independently or R4 and R5 together form a moiety of formula - (CH 2) A y- (y represents an integer of 4 or 5) crosslink is formed. It has been described that the present invention relates to pharmaceutical preparations having one or more of said indole derivatives and their use as medicaments. Also disclosed is the use of said indole derivatives in estrogen replacement therapy and / or for the manufacture of a medicament for the therapeutic or prophylactic treatment of estrogen related disorders or diseases of breast cancer.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022070483-A1
priorityDate 1993-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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