| abstract |
(57) Summary: Formula I with good bioavailability useful as an agent in the treatment of obesity, gastric acid hypersecretion in the gastrointestinal tract, gastrin-dependent tumors or as an antipsychotic Novel cholecystokinin antagonists are disclosed. In addition, this compound is an anxiolytic and anti-ulcer agent. The compounds are also useful in preventing the response to withdrawal from chronic treatment by the use of nicotine, diazepam, alcohol, cocaine, coffee or opioids. The compounds of the invention are also useful in treating and / or preventing panic. Also disclosed are pharmaceutical compositions and methods of making the compounds. An important feature of the present invention is the absolute oral bioavailability of the compound. |