| abstract |
(57) [Summary]nThe present invention provides a transgenic non-human animal in which a gene encoding a colony stimulating factor is specifically damaged. In a specific example, the invention provides a mouse with impaired expression of GM-CSF, G-CSF and / or CSF-1. These animals do not produce any bioactive CSF of their respective types. These are useful as models for various conditions, especially for testing therapeutic methods. |